Sandhoff's disease

noun

Sand·​hoff's disease ˈsand-ˌhȯfs- 

variants or Sandhoff disease

-ˌhȯf- 

: a hereditary disorder of lipid metabolism that is closely related to or a variant of Tay-Sachs disease, typically affects individuals of non-Jewish ancestry, and is characterized by great reduction in or absence of both hexosaminidase A and hexosaminidase B